Quality of life in childhood epilepsy with lateralized epileptogenic foci

K. A. Mathiak , Małgorzata Łuba , K. Mathiak , Katarzyna Karzel , Tomasz Wolańczyk , Elżbieta Szczepanik , Paweł Ostaszewski

Abstract

Background: Measuring quality of life (QOL) helps to delineate mechanisms underlying the interaction of disease and psychosocial factors. In adults, epileptic foci in the left temporal lobe led to lower QOL and higher depression and anxiety as compared to the right-sided foci. No study addressed the development of QOL disturbances depending on the lateralization of epileptogenic focus. The objective of our study was to examine QOL in children with lateralized epileptiform discharges. Methods: Thirty-one parents of children with epilepsy filled the Health-Related Quality of Life in Childhood Epilepsy Questionnaire (QOLCE). Fifteen children had foci in the left hemisphere and sixteen in the right, as verified with Electroencephalography (EEG) examinations. Results: We found a significant correlation between foci lateralization and reduced QOL (Spearman’s rho = 0.361, p < 0.046). Children with right hemispheric foci exhibited lower overall QOL, particularly in five areas: anxiety, social-activities, stigma, general-health, and quality-of-life. Conclusions: We demonstrated for the first time that in children left- and right-hemispheric foci were associated with discordant QOL scores. Unlike in adults, foci in the right hemisphere led to worse emotional and social functioning demonstrating that seizures impact the brain differentially during development.
Author K. A. Mathiak
K. A. Mathiak,,
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, Małgorzata Łuba
Małgorzata Łuba,,
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, K. Mathiak
K. Mathiak,,
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, Katarzyna Karzel
Katarzyna Karzel,,
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, Tomasz Wolańczyk
Tomasz Wolańczyk,,
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, Elżbieta Szczepanik
Elżbieta Szczepanik,,
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, Paweł Ostaszewski (Wydział Psychologii)
Paweł Ostaszewski,,
- Wydział Psychologii
Journal seriesBMC Neurology, ISSN 1471-2377, (A 30 pkt)
Issue year2010
Vol10:69
Pages1-7
Publication size in sheets0
DOIDOI:10.1186/1471-2377-10-69
URL http://www.biomedcentral.com/content/pdf/1471-2377-10-69.pdf
Languageen angielski
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Mathiak-et-al-BMC-Neurology-2010.pdf of 14-09-2015
228.93 KB
Score (nominal)27
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Dorobek Naukowy - Preview URLhttp://dn.swps.edu.pl/Podglad.aspx?WpisID=4427
Dorobek Naukowy - Approve URLhttp://dn.swps.edu.pl/Biuro/ZatwierdzanieWpisu.aspx?WpisID=4427
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* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.
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