Involvement of retrosplenial cortex in classical conditioning

Aleksandra Radwańska , Weronika Dębowska , Monika Liguz-Lecznar , Aneta Brzezicka , Małgorzata Kossut , Anita Cybulska-Klosowicz

Abstract

The cingulate cortex, which comprises of two major subdivisions - anterior cingulate cortex (CG) and retrosplenial cortex (RSP), is implicated in many cognitive functions. The RSP is an important node in the systemic integration network. Studies point to its role in learning that involves spatial stimuli and navigation. Relatively little is known about its involvement in simple learning such as classical conditioning. We examined the involvement of the two cytoarchitectonic divisions, agranular and granular, of the rostral and caudal RSP in a delay conditioning, where stimulation of the facial vibrissae was paired with a tail shock. During the conditioning session the [(14)C]-2-deoxyglucose (2DG) brain mapping was performed. Effectiveness of conditioning was assessed with frequency of head movements, which decreased in the course of the conditioning. 2DG uptake in RSP and additionally in CG was examined in conditioned, pseudoconditioned and stimulated control groups. The metabolic labeling was elevated in caudal and rostral both RSP and CG in the conditioned group, but not in animals which received CS or UCS alone. Comparison between conditioned and pseudoconditioned groups showed the specific activation by associative learning in both divisions of the rostral RSP and rostral CG. Counts of c-Fos expressing nuclei confirmed activation of the rostral RSP in the CS+UCS group. These data support the concept of RSP as structure that, besides its recognized role in visuospatial learning, monitors and reacts to activity of brain systems responsible for other types of learning and, together with CG, subserve cognitive processes, with simple associative learning among them.
Author Aleksandra Radwańska
Aleksandra Radwańska,,
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, Weronika Dębowska
Weronika Dębowska,,
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, Monika Liguz-Lecznar
Monika Liguz-Lecznar,,
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, Aneta Brzezicka (Wydział Psychologii)
Aneta Brzezicka,,
- Wydział Psychologii
, Małgorzata Kossut (Wydział Psychologii)
Małgorzata Kossut,,
- Wydział Psychologii
, Anita Cybulska-Klosowicz
Anita Cybulska-Klosowicz,,
-
Journal seriesBehavioural Brain Research, ISSN 0166-4328, (A 30 pkt)
Issue year2010
Vol214(2)
Pages231-239
Publication size in sheets0.5
Keywords in EnglishRetrosplenial cortex; Classical conditioning; [14C]-2-deoxyglucose mapping; c-Fos
DOIDOI:10.1016/j.bbr.2010.05.042
URL http://www.ncbi.nlm.nih.gov/pubmed/20561962
Languageen angielski
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Radavanska-et-al-2010.pdf of 14-09-2015
1.93 MB
Score (nominal)32
Citation count*15 (2020-09-17)
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Dorobek Naukowy - Preview URLhttp://dn.swps.edu.pl/Podglad.aspx?WpisID=5849
Dorobek Naukowy - Approve URLhttp://dn.swps.edu.pl/Biuro/ZatwierdzanieWpisu.aspx?WpisID=5849
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* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.
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