fMRI evidence of a relationship between hypomania and both increased goal-sensitivity and positive outcome-expectancy bias

Noreen O'Sullivan , Remigiusz Szczepanowski , Wael El-Deredy , Liam Mason , Richard Bentall

Abstract

Background: Mania is argued to stem from the dysfunctional processing of reward. Investigation of hypo- mania in healthy samples has the potential to offer refined insight into the particular aspects of reward processing in mania that are dysfunctional. Method: In this study, fMRI was employed in contrasting a sample of 12 unmedicated subclinical hypo- manic individuals with a sample of 12 unmedicated controls in order to investigate reward-related processing in a reinforcement-learning task. Results: Four findings in the hypomania-prone group relative to the control group supported atypical reward processing. Firstly, striatal activation that correlated with reward value and prediction error was stronger in response to cues and outcomes respectively, consistent with hypomania being related to an enhanced perception of the value of goals that may lead to reward. Secondly, value-related medial temporal activation was stronger in response to cues, suggesting that in hypomania-prone individuals, stimuli in memory were represented in accordance with their perceived value. Thirdly, these effects failed to be modulated by the actual value of outcomes, suggesting that hypomania is related to a decreased ability to discriminate between cues differing in value. Fourthly, increased insula activation in response to expected, but absent, reward was consistent with a bias towards expecting positive outcomes in decision-making. Conclusion: Together, the findings suggest that enhanced perception and representation of goal-value that nonetheless fails to discriminate on the basis of actual goal-value, coupled with a positive outcome- expectancy bias, could be causally related to insatiable and indiscriminate reward seeking in mania.​
Author Noreen O'Sullivan
Noreen O'Sullivan,,
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, Remigiusz Szczepanowski (Wydział Zamiejscowy we Wrocławiu)
Remigiusz Szczepanowski,,
- Wydział Zamiejscowy we Wrocławiu
, Wael El-Deredy
Wael El-Deredy,,
-
, Liam Mason
Liam Mason,,
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, Richard Bentall
Richard Bentall,,
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Journal seriesNeuropsychologia, ISSN 0028-3932, (A 40 pkt)
Issue year2011
VolVolumen 49, wydanie 10
Pages2825–2835
Publication size in sheets0
DOIDOI:http://dx.doi.org/10.1016/j.neuropsychologia.2011.06.008
URL http://www.sciencedirect.com/science/article/pii/S0028393211002892
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nadbitka-neuro-2011.pdf of 14-09-2015
198.86 KB
Score (nominal)40
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Dorobek Naukowy - Preview URLhttp://dn.swps.edu.pl/Podglad.aspx?WpisID=5929
Dorobek Naukowy - Approve URLhttp://dn.swps.edu.pl/Biuro/ZatwierdzanieWpisu.aspx?WpisID=5929
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* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.
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