Cognitive inhibition in patients with medial orbitofrontal damage

Iwona Szatkowska , Piotr Bojarski , Anna Grabowska , Olga Szymańska

Abstract

Inhibition underlies cognitive processes such as overcoming habitual responses, suppressing of goal-irrelevant information, and switching of attention between stimuli or task rules. These processes are thought to depend on the frontal lobes. However, the precise role of the ventral frontal regions (orbitofrontal cortex) in these processes remains elusive. In the present study, our goal was to clarify the role of the orbitofrontal cortex in cognitiveinhibition by examining the effects of focal lesions to the medial orbitofrontal cortex (posterior part of the gyrus rectus) on performance in tasks that required inhibitory control. Patients who had undergone surgery for an anterior communicating artery aneurysm and normal control subjects (C) participated in the study. The patients were subdivided into three groups: those with resection of the left (LGR+) or right (RGR+) gyrus rectus, and without such a resection (GR-). The Stroop Color-Word test, Trail Making B test, and the Category test were used as instruments for assessing response inhibition, switching between concrete stimuli, and switching between abstract task rules, respectively. In addition, the Digit Symbol test was used to examine sustained attention and processing speed. In the Stroop Color-Word test, the RGR+ group performed worse than all other groups. In the Trail Making B test, the RGR+ and LGR+ groups performed worse than both the GR- and C groups. In the Category test and Digit Symbol test, the groups did not differ significantly from each other. Our study indicates a specific contribution of the medial orbitofrontal cortex to response inhibition and stimulus-based switching of attention.
Author Iwona Szatkowska
Iwona Szatkowska,,
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, Piotr Bojarski
Piotr Bojarski,,
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, Anna Grabowska
Anna Grabowska,,
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, Olga Szymańska (USSH)
Olga Szymańska,,
- SWPS University of Social Sciences and Humanities
Journal seriesExperimental Brain Research, ISSN 0014-4819, (C 25 pkt)
Issue year2007
Vol181
Pages109-115
Publication size in sheets0
ASJC Classification2800 General Neuroscience
Languageen angielski
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Cognitive-inhibition-in-patients-with-medial-orbitofrontal-damage.pdf of 14-09-2015
315.34 KB
Not used for evaluationyes
Score (nominal)0
Publication indicators Scopus SNIP (Source Normalised Impact per Paper): 2007 = 1.024; WoS Impact Factor: 2007 = 2.027 (2) - 2007=2.477 (5)
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Dorobek Naukowy - Preview URLhttp://dn.swps.edu.pl/Podglad.aspx?WpisID=8523
Dorobek Naukowy - Approve URLhttp://dn.swps.edu.pl/Biuro/ZatwierdzanieWpisu.aspx?WpisID=8523
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* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.
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