Cognitive subtypes of dyslexia are characterized by distinct patterns of grey matter volume

Katarzyna Jednoróg , Natalia Gawron , Artur Marchewka , Stefan Heim , Anna Grabowska

Abstract

The variety of different causal theories together with inconsistencies about the anatomical brain markers emphasize the heterogeneity of developmental dyslexia. Attempts were made to test on a behavioral level the existence of subtypes of dyslexia showing distinguishable cognitive deficits. Importantly, no research was directly devoted to the investigation of structural brain correlates of these subtypes. Here, for the first time, we applied voxelbased morphometry (VBM) to study grey matter volume (GMV) differences in a relatively large sample (n = 46) of dyslexic children split into three subtypes based on the cognitive deficits: phonological, rapid naming, magnocellular/ dorsal, and auditory attention shifting. VBM revealed GMV clusters specific for each studied group including areas of left inferior frontal gyrus, cerebellum, right putamen, and bilateral parietal cortex. In addition, using discriminant analysis on these clusters 79 % of cross-validated cases were correctly re-classified into four groups (controls vs. three subtypes). Current results indicate that dyslexia may result from distinct cognitive impairments characterized by distinguishable anatomical markers.
Author Katarzyna Jednoróg
Katarzyna Jednoróg,,
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, Natalia Gawron
Natalia Gawron,,
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, Artur Marchewka
Artur Marchewka,,
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, Stefan Heim
Stefan Heim,,
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, Anna Grabowska (Wydział Psychologii)
Anna Grabowska,,
- Wydział Psychologii
Journal seriesBrain Structure & Function, ISSN 1863-2653, (A 45 pkt)
Issue year2014
Vol219
No5
Pages1697-1707
Publication size in sheets0.5
Keywords in EnglishVBM, Dyslexia, Cognitive deficits, Heterogeneity
ASJC Classification2722 Histology; 2800 General Neuroscience; 2702 Anatomy
DOIDOI:10.1007/s00429-013-0595-6
URL http://link.springer.com/article/10.1007%2Fs00429-013-0595-6#/page-1
Languageen angielski
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Score (nominal)45
Publication indicators Scopus SNIP (Source Normalised Impact per Paper): 2014 = 1.04; WoS Impact Factor: 2014 = 5.618 (2) - 2014=6.935 (5)
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Dorobek Naukowy - Preview URLhttp://dn.swps.edu.pl/Podglad.aspx?WpisID=17216
Dorobek Naukowy - Approve URLhttp://dn.swps.edu.pl/Biuro/ZatwierdzanieWpisu.aspx?WpisID=17216
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* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.
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