Cognitive subtypes of dyslexia are characterized by distinct patterns of grey matter volume
Authors:
- Katarzyna Jednoróg,
- Natalia Gawron,
- Artur Marchewka,
- Stefan Heim,
- Anna Grabowska
Abstract
The variety of different causal theories together with inconsistencies about the anatomical brain markers emphasize the heterogeneity of developmental dyslexia. Attempts were made to test on a behavioral level the existence of subtypes of dyslexia showing distinguishable cognitive deficits. Importantly, no research was directly devoted to the investigation of structural brain correlates of these subtypes. Here, for the first time, we applied voxelbased morphometry (VBM) to study grey matter volume (GMV) differences in a relatively large sample (n = 46) of dyslexic children split into three subtypes based on the cognitive deficits: phonological, rapid naming, magnocellular/ dorsal, and auditory attention shifting. VBM revealed GMV clusters specific for each studied group including areas of left inferior frontal gyrus, cerebellum, right putamen, and bilateral parietal cortex. In addition, using discriminant analysis on these clusters 79 % of cross-validated cases were correctly re-classified into four groups (controls vs. three subtypes). Current results indicate that dyslexia may result from distinct cognitive impairments characterized by distinguishable anatomical markers.
- Record ID
- IMPORT-ARTICLE-00017216
- Author
- Journal series
- Brain Structure & Function, ISSN 1863-2653
- Issue year
- 2014
- Vol
- 219
- No
- 5
- Pages
- 1697-1707
- Publication size in sheets
- 0.50
- Keywords in English
- VBM, Dyslexia, Cognitive deficits, Heterogeneity
- ASJC Classification
- ; ;
- DOI
- DOI:10.1007/s00429-013-0595-6 opening in a new tab
- URL
- http://link.springer.com/article/10.1007%2Fs00429-013-0595-6#/page-1 opening in a new tab
- Language
- (en) English
- File
-
- File: 1
- Cognitive-subtypes-of-dyslexia-are-characterized-by-distinct-patterns-of-grey-matter-volume-1.jpg
- of 14-09-2015
1 MB
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- Additional file
-
- File: 1
- Scan-ag.pdf
-
- Score (nominal)
- 45
- Publication indicators
- : 2014 = 1.040; : 2014 = 5.618 (2) - 2014=6.935 (5)
- Additional fields
- Dorobek Naukowy - Preview URL: http://dn.swps.edu.pl/Podglad.aspx?WpisID=17216
- Dorobek Naukowy - Approve URL: http://dn.swps.edu.pl/Biuro/ZatwierdzanieWpisu.aspx?WpisID=17216
Share
- Uniform Resource Identifier
- http://192.168.13.97/info/article/IMPORT-ARTICLE-00017216/
* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perishopening in a new tab system.