Cortical source analysis of resting state EEG data in children with attention deficit hyperactivity disorder

Maliheh Ahmadi , Kamran Kazemi , Katarzyna Kuć , Anita Cybulska-Kłosowicz , Marta Zakrzewska , Ewa Racicka-Pawlukiewicz , Mohammad Sadegh Helfroush , Ardalan Aarabi

Abstract

Objective This study investigated age-dependent and subtype-related alterations in electroencephalography (EEG) power spectra and current source densities (CSD) in children with attention deficit and hyperactivity disorder (ADHD). Methods We performed spectral and cortical source (exact low-resolution electromagnetic tomography, eLORETA) analyses using resting state EEG recordings from 40 children (8–16 years) with combined and inattentive subtypes of ADHD and 41 age-matched healthy controls (HC). Group differences in EEG spectra and CSD were investigated at each scalp location, voxel and cortical region in delta, theta, alpha and beta bands. We also explored associations between topographic changes in EEG power and CSD and age. Results Compared to healthy controls, combined ADHD subtype was characterized with significantly increased diffuse theta/beta power ratios (TBR) with a widespread decrease in beta CSD. Inattentive ADHD subtype presented increased TBR in all brain regions except in posterior areas with a global increase in theta source power. In both ADHD and HC, older age groups showed significantly lower delta source power and TBR and higher alpha and beta source power than younger age groups. Compared to HC, ADHD was characterized with increases in theta fronto-central and temporal source power with increasing age. Conclusions Our results confirm that TBR can be used as a neurophysiological biomarker to differentiate ADHD from healthy children at both the source and sensor levels. Significance Our findings emphasize the importance of performing the source imaging analysis in order to better characterize age-related changes in resting-state EEG activity in ADHD and controls.
Author Maliheh Ahmadi
Maliheh Ahmadi,,
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, Kamran Kazemi
Kamran Kazemi,,
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, Katarzyna Kuć (Wydział Psychologii w Warszawie)
Katarzyna Kuć,,
- Wydział Psychologii w Warszawie
, Anita Cybulska-Kłosowicz
Anita Cybulska-Kłosowicz,,
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, Marta Zakrzewska (USSH)
Marta Zakrzewska,,
- SWPS University of Social Sciences and Humanities
, Ewa Racicka-Pawlukiewicz
Ewa Racicka-Pawlukiewicz,,
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, Mohammad Sadegh Helfroush
Mohammad Sadegh Helfroush,,
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, Ardalan Aarabi
Ardalan Aarabi,,
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Journal seriesClinical Neurophysiology, ISSN 1388-2457, e-ISSN 1872-8952, (N/A 100 pkt)
Issue year2020
Vol131
No9
Pages2115-2130
Publication size in sheets0.75
ASJC Classification2728 Clinical Neurology; 2737 Physiology (medical); 2808 Neurology; 2809 Sensory Systems
DOIDOI:10.1016/j.clinph.2020.05.028
URL https://www.sciencedirect.com/science/article/pii/S1388245720303643#!
Languageen angielski
File
Cortical source tekst.pdf 5.7 MB
Additional file
Cortical source osw Kuc.docx 40.85 KB
Score (nominal)100
Score sourcejournalList
Publication indicators Scopus SNIP (Source Normalised Impact per Paper): 2018 = 1.358; WoS Impact Factor: 2018 = 3.675 (2) - 2018=3.743 (5)
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