The neural correlates of specific executive dysfunctions in Parkinson's disease

Ludwika Gawrys , Marcel Falkiewicz , Artur Pilacinski , Monika Riegel , Ewa Piatkowska-Janko , Piotr Bogorodzki , Tomasz Wolak , Renata Andrysiak , Leszek Krolicki , Radosław Kulinski , Dariusz Koziorowski , Piotr Janik , Krystyna Rymarczyk , Anna Grabowska , Leszek Kaczmarek , Iwona Szatkowska


Several functional neuroimaging studies in patients with Parkinson�s disease (PD) have suggested that changes in the fronto-parietal-striatal networks are associated with deficits in executive functioning. However, executive functions (EF) are multifaceted and include three dissociable components: working memory, response inhibition, and task-switching. This study investigated which component of executive functioning is most strongly associated with fronto-parietal-striatal efficiency in PD. PD patients (with and without executive dysfunction), and age-matched healthy subjects, completed a battery of cognitive tests previously shown to discriminate among the three EF components. Principal component analysis conducted on the selected cognitive test variables yielded three expected EF components. The component scores were used in regression analysis to assess the relationship between the EF efficiency and blood oxygenation level-dependent (BOLD) signal related to performing the n-back,
Author Ludwika Gawrys
Ludwika Gawrys,,
, Marcel Falkiewicz
Marcel Falkiewicz,,
, Artur Pilacinski
Artur Pilacinski,,
, Monika Riegel
Monika Riegel,,
, Ewa Piatkowska-Janko
Ewa Piatkowska-Janko,,
, Piotr Bogorodzki
Piotr Bogorodzki,,
, Tomasz Wolak
Tomasz Wolak,,
, Renata Andrysiak
Renata Andrysiak,,
, Leszek Krolicki
Leszek Krolicki,,
, Radosław Kulinski
Radosław Kulinski,,
et al.`
Journal seriesActa Neurobiologiae Experimentalis, ISSN 0065-1400, (A 20 pkt)
Issue year2014
Pages465 - 478
Publication size in sheets0.65
Keywords in EnglishParkinson�s disease, executive function, working memory, inhibition, task-switching, principal components analysis, functional magnetic resonance imaging, fMRI, Aged, Brain, Brain Mapping, Case-Control Studies, Cognition Disorders, Executive Function, Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Memory, Short-Term, Middle Aged, Neuropsychological Tests, Oxygen, Parkinson Disease, Principal Component Analysis, Parkinson's Disease, Response Inhibition, Short Term Memory, Executive Function, Task Switching, Neural Networks, Functional Magnetic Resonance Imaging
ASJC Classification2700 General Medicine; 2800 General Neuroscience
Languageen angielski
Score (nominal)20
Publication indicators Scopus SNIP (Source Normalised Impact per Paper): 2014 = 0.827; WoS Impact Factor: 2014 = 1.286 (2) - 2014=1.732 (5)
Citation count*
Share Share

Get link to the record

* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.
Are you sure?