The neural correlates of specific executive dysfunctions in Parkinson's disease
Authors:
- Ludwika Gawrys,
- Marcel Falkiewicz,
- Artur Pilacinski,
- Monika Riegel,
- Ewa Piatkowska-Janko,
- Piotr Bogorodzki,
- Tomasz Wolak,
- Renata Andrysiak,
- Leszek Krolicki,
- Radosław Kulinski,
- Dariusz Koziorowski,
- Piotr Janik,
- Krystyna Rymarczyk,
- Anna Grabowska,
- Leszek Kaczmarek,
- Iwona Szatkowska
Abstract
Several functional neuroimaging studies in patients with Parkinson�s disease (PD) have suggested that changes in the fronto-parietal-striatal networks are associated with deficits in executive functioning. However, executive functions (EF) are multifaceted and include three dissociable components: working memory, response inhibition, and task-switching. This study investigated which component of executive functioning is most strongly associated with fronto-parietal-striatal efficiency in PD. PD patients (with and without executive dysfunction), and age-matched healthy subjects, completed a battery of cognitive tests previously shown to discriminate among the three EF components. Principal component analysis conducted on the selected cognitive test variables yielded three expected EF components. The component scores were used in regression analysis to assess the relationship between the EF efficiency and blood oxygenation level-dependent (BOLD) signal related to performing the n-back,
- Record ID
- SWPS1e537e469918446f84118598fdb89b6c
- Author
- Journal series
- Acta Neurobiologiae Experimentalis, ISSN 0065-1400
- Issue year
- 2014
- Vol
- 74
- No
- 4
- Pages
- 465 - 478
- Publication size in sheets
- 0.65
- Keywords in English
- Parkinson�s disease, executive function, working memory, inhibition, task-switching, principal components analysis, functional magnetic resonance imaging, fMRI, Aged, Brain, Brain Mapping, Case-Control Studies, Cognition Disorders, Executive Function, Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Memory, Short-Term, Middle Aged, Neuropsychological Tests, Oxygen, Parkinson Disease, Principal Component Analysis, Parkinson's Disease, Response Inhibition, Short Term Memory, Executive Function, Task Switching, Neural Networks, Functional Magnetic Resonance Imaging
- ASJC Classification
- ;
- URL
- http://search.ebscohost.com/login.aspx?direct=true&db=psyh&AN=2015-06389-010&lang=pl&site=ehost-live opening in a new tab
- Language
- (en) English
- Score (nominal)
- 20
- Publication indicators
- : 2014 = 0.827; : 2014 = 1.286 (2) - 2014=1.732 (5)
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- Uniform Resource Identifier
- http://192.168.13.97/info/article/SWPS1e537e469918446f84118598fdb89b6c/
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