Working Memory Load-related Theta Power Decreases in Dorsolateral Prefrontal Cortex Predict Individual Differences in Performance

Aneta Brzezicka , Jan Kamiński , Chrystal M. Reed , J.M Chung , A.N Mamelak , U. Rutishauser

Abstract

Holding information in working memory (WM) is an active and effortful process that is accompanied by sustained load-dependent changes in oscillatory brain activity. These proportional power increases are often reported in EEG studies recording theta over frontal midline sites. Intracranial recordings, however, yield mixed results, depending on the brain area being recorded from. We recorded intracranial EEG with depth electrodes in 13 patients with epilepsy who were performing a Sternberg WM task. Here, we investigated patterns of theta power changes as a function of memory load during maintenance in three areas critical for WM: dorsolateral prefrontal cortex (DLPFC), dorsal ACC (dACC), and hippocampus. Theta frequency power in both hippocampus and dACC increased during maintenance. In contrast, theta frequency power in the DLPFC decreased during maintenance, and this decrease was proportional to memory load. Only the power decreases in DLPFC, but not the power increases in hippocampus and dACC, were predictive of behavior in a given trial. The extent of the load-related theta power decreases in the DLPFC in a given participant predicted a participant's RTs, revealing that DLPFC theta explains individual differences in WM ability between participants. Together, these data reveal a pattern of theta power decreases in the DLPFC that is predictive of behavior and that is opposite of that in other brain areas. This result suggests that theta band power changes serve different cognitive functions in different brain areas and specifically that theta power decreases in DLPFC have an important role in maintenance of information
Author Aneta Brzezicka (Wydział Psychologii)
Aneta Brzezicka,,
- Wydział Psychologii
, Jan Kamiński
Jan Kamiński,,
-
, Chrystal M. Reed
Chrystal M. Reed,,
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, J.M Chung
J.M Chung,,
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, A.N Mamelak
A.N Mamelak,,
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, U. Rutishauser
U. Rutishauser,,
-
Journal seriesJournal of Cognitive Neuroscience, ISSN 0898-929X, (N/A 140 pkt)
Issue year2019
Vol31
No9
Pages1290-1307
Publication size in sheets0.85
ASJC Classification2805 Cognitive Neuroscience
DOIDOI:10.1162/jocn_a_01417
URL https://www.ncbi.nlm.nih.gov/pubmed/31037988
Languageen angielski
Additional file
Oswiadczenie_A.Brzezicka.docx 18.04 KB
Score (nominal)140
Score sourcejournalList
Publication indicators Scopus SNIP (Source Normalised Impact per Paper): 2017 = 1.066; WoS Impact Factor: 2017 = 3.468 (2) - 2017=3.953 (5)
Citation count*6 (2020-10-16)
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