The relationship between cingulum bundle integrity and different aspects of executive functions in chronic schizophrenia

Ernest Tyburski , Monika Mak , Agnieszka Samochowiec , Piotr Plichta , Maksymilian Bielecki , Katarzyna Rek-Owodziń , Piotr Podwalski , Krzysztof Rudkowski , Katarzyna Waszczuk , Justyna Pełka-Wysiecka , Jolanta Kucharska-Mazur , Wojciech Andrusewicz , Błażej Misiak , Magdalena Kerestey , Anna Michalczyk , Shane T. Mueller , Leszek Sagan , Jerzy Samochowiec

Abstract

Background: Evidence suggests that disruption in the cingulum bundle (CB) may influence executive dysfunctions in schizophrenia, but findings are still inconsistent. Using diffusion tensor imaging tractography, we investigated the differences in fiber integrity between schizophrenia patients and healthy controls together with the association between fiber integrity and executive functions. Methods: Thirty-two patients with chronic schizophrenia and 24 healthy controls took part in the study. Both groups were matched for age, sex, and years of education. Assessment of cognitive functions was performed using the Berg Card Sorting Test (BCST), the Color Trail Test (CTT), and the Stroop Color-Word Test (SCWT). Results: Results showed group differences, bilaterally (left and right) in fractional anisotropy (FA) of the CB, where patients showed less anisotropy than controls. Moreover, normal asymmetry (left FA > right FA) in the CB in schizophrenia was found. There were no group differences in mean diffusivity (MD). Patients had a similar but reduced profile of executive functions compared to healthy controls. However, when premorbid IQ was controlled for, the differences were no longer statistically significant. In schizophrenia patients, a negative correlation was found between FA of the left CB and perseverative errors in the BCST. Conclusions: These findings provide evidence that CB disruption appears in schizophrenia patients and might account for impairments of executive processes, including concept formation.
Author Ernest Tyburski (Wydział Psychologii i Prawa w Poznaniu)
Ernest Tyburski,,
- Wydział Psychologii i Prawa w Poznaniu
, Monika Mak
Monika Mak,,
-
, Agnieszka Samochowiec
Agnieszka Samochowiec,,
-
, Piotr Plichta
Piotr Plichta,,
-
, Maksymilian Bielecki
Maksymilian Bielecki,,
-
, Katarzyna Rek-Owodziń
Katarzyna Rek-Owodziń,,
-
, Piotr Podwalski
Piotr Podwalski,,
-
, Krzysztof Rudkowski
Krzysztof Rudkowski,,
-
, Katarzyna Waszczuk
Katarzyna Waszczuk,,
-
, Justyna Pełka-Wysiecka
Justyna Pełka-Wysiecka,,
-
et al.`
Journal seriesProgress in Neuro-Psychopharmacology & Biological Psychiatry, [Progress in Neuro-Psychopharmacology and Biological Psychiatry], ISSN 0278-5846, e-ISSN 1878-4216, (N/A 100 pkt)
Issue year2020
Vol102
Pages1-8
Publication size in sheets0.5
Keywords in EnglishExecutive functions, Cingulum bundle, Schizophrenia, Diffusion tensor imaging, White matter integrity, Fractional anisotropy
ASJC Classification2803 Biological Psychiatry; 3004 Pharmacology
DOIDOI:10.1016/j.pnpbp.2020.109955
URL https://doi.org/10.1016/j.pnpbp.2020.109955
Languageen angielski
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The relationship between cingulum.pdf 560.7 KB
Oświadczenie 3.pdf 2.47 MB
Score (nominal)100
Score sourcejournalList
Publication indicators Scopus SNIP (Source Normalised Impact per Paper): 2016 = 1.12; WoS Impact Factor: 2018 = 4.315 (2) - 2018=4.159 (5)
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