Prevalence and impact of autoimmune thyroid disease on myasthenia gravis course

Justyna Kubiszewska , Beata Szyluk , Piotr Szczudlik , Zbigniew Bartoszewicz , Małgorzata Dutkiewicz , Maksymilian Bielecki , Tomasz Bednarczuk , Anna Kostera-Pruszczyk

Abstract

Objectives: Autoimmune thyroid diseases (ATDs) frequently accompany myasthenia gravis (MG) and may influence its course. We aimed to determine the association and impact of ATD with early-(< 50 years), late-onset MG, or thymoma-MG. Materials and Methods: Prevalence of ATD was measured in a cross-sectional study of 343 consecutive patients with MG (236 F, 107 M) aged 4–89 years; 83.8% were seropositive, in 2.9%, anti-MuSK antibodies were detected. Concentrations of antithyroid peroxidase antibodies, antithyroglobulin antibodies, antithyrotropin receptor antibodies, and TSH level were measured in all patients. MG clinical course, treatment received, and treatment results were evaluated. Results: Autoimmune thyroid diseases were diagnosed in 92 (26.8%) of MG patients including 4.4% with Graves (GD), 9% with Hashimoto thyroiditis (HT), and 13.4% with antithyroid antibodies only. GD patients had ocular symptoms more often than patients with antithyroid antibodies or HT (p = .008). ATD prevalence was comparable in MG with early and late onset, while non-ATDs were more frequent in thymoma-MG (p = .049). Immunosuppressive therapy was less frequently needed in the patients with MG and ATD, indirectly indicating milder MG course (p = .005). Risk of myasthenic crisis and the results of treatment did not differ between patients with and without ATD. Conclusions: Autoimmune thyroid diseases are frequently accompanied by early-and late-onset MG, while thymoma-MG is related to higher risk of non-ATD. Myasthenia coexisting with ATD follows milder course than MG alone.
Author Justyna Kubiszewska
Justyna Kubiszewska,,
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, Beata Szyluk
Beata Szyluk,,
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, Piotr Szczudlik
Piotr Szczudlik,,
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, Zbigniew Bartoszewicz
Zbigniew Bartoszewicz,,
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, Małgorzata Dutkiewicz
Małgorzata Dutkiewicz,,
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, Maksymilian Bielecki (Wydział Psychologii)
Maksymilian Bielecki,,
- Wydział Psychologii
, Tomasz Bednarczuk
Tomasz Bednarczuk,,
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, Anna Kostera-Pruszczyk
Anna Kostera-Pruszczyk,,
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Journal seriesBrain and Behavior, ISSN 2162-3279, (A 20 pkt)
Issue year2016
Noe00537
Pages1-6
Publication size in sheets0.3
Keywords in Englishautoimmune thyroid diseases, Graves' disease, Hashimoto's thyroiditis, myasthenia gravis
ASJC Classification2802 Behavioral Neuroscience
DOIDOI:10.1002/brb3.537
URL http://dx.doi.org/10.1002/brb3.537
Languageen angielski
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Kubiszewska_et_al-2016-Brain_and_Behavior.pdf 323.72 KB
Bielecki_osw.pdf 155.33 KB
Score (nominal)20
Publication indicators Scopus SNIP (Source Normalised Impact per Paper): 2016 = 0.707; WoS Impact Factor: 2016 = 2.157 (2) - 2016=2.506 (5)
Citation count*16 (2019-10-14)
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