Psychophysical well-being profiles in patients before hematopoietic stem cell transplantation

Aleksandra Kroemeke , Zuzanna Kwissa-Gajewska , Małgorzata Sobczyk-Kruszelnicka

Abstract

Objectives The literature offers very few in-depth reports on the time directly before hematopoietic stem cell transplantation (HSCT). Also, researchers have focused on selected aspects of psychophysical well-being and treated the sample as homogeneous. Thus, we chose to investigate distinct multidimensional well-being profiles (including anxiety, depressive symptoms, and health-related quality of life [HRQOL] domains) among patients just before HSCT, as well as profile predictors (generalized self-efficacy) and outcomes (transplant appraisal) on the basis of the transactional stress model.

Methods Depression (CES-D), anxiety (HADS-A), HRQOL (EORTC QOL-C30), generalized self-efficacy (GSES), and transplant appraisal (single-item scale referred to threat and challenge) were measured in 290 patients (56.9% male; mean age = 47.28, SD = 13.79) after admission for HSCT (67.2% autologous). Unconditional and conditional latent profile analyses were applied.

Results Four latent well-being profiles were identified: well-functioning (51%, highest well-being in all aspects), dysfunctional (10%, weakest functioning in all aspects), and 2 profiles with moderate HRQOL and high (5.6%) or low (33.4%) anxiety and depressive symptoms. Generalized self-efficacy predicted profile membership, controlling for demographic and clinical variables. The highest levels were observed in the well-functioning group (P < .01). Appraisal was predicted by latent profile analyses classes: low threat in the well-functioning group (P < .001) and the highest threat and challenge in the dysfunctional group (P < .01).

Conclusions The findings highlight the diverse nature of well-being in pre-HSCT patients and the manner in which transplant appraisal and generalized self-efficacy are related to different profiles of pre-HSCT multidimensional well-being, thus indicating the practical implications of the study.

Author Aleksandra Kroemeke (Wydział Psychologii)
Aleksandra Kroemeke,,
- Wydział Psychologii
, Zuzanna Kwissa-Gajewska (Wydział Psychologii)
Zuzanna Kwissa-Gajewska,,
- Wydział Psychologii
, Małgorzata Sobczyk-Kruszelnicka
Małgorzata Sobczyk-Kruszelnicka,,
-
Journal seriesPsycho-Oncology, ISSN 1057-9249, (A 40 pkt)
Issue year2018
Vol27
No3
Pages962-968
Publication size in sheets0.5
Keywords in Englishanxiety, cancer, depression, hematopoietic stem cell transplantation, latent profile analysis, oncology, quality of life, self-efficacy
ASJC Classification2738 Psychiatry and Mental health; 2730 Oncology; 3205 Experimental and Cognitive Psychology
DOIDOI:10.1002/pon.4619
URL http://dx.doi.org/10.1002/pon.4619
Languageen angielski
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Kroemeke_et_al-2018-Psycho-Oncology.pdf 336.7 KB
Additional file
2018-03-13-10-30-29-852.pdf 32.56 KB
2018-03-14-12-54-09-229.pdf 23.83 KB
Score (nominal)40
Score sourcejournalList
Publication indicators Scopus SNIP (Source Normalised Impact per Paper): 2016 = 1.564; WoS Impact Factor: 2017 = 3.455 (2) - 2017=4.107 (5)
Citation count*2 (2020-09-25)
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