Altered Functional Connectivity Differences in Salience Network as a Neuromarker of Suicide Risk in Euthymic Bipolar Disorder Patients

Anna Sobczak , Bartosz Bohaterewicz , Tadeusz Marek , Magdalena Fafrowicz , Dominika Dudek , Marcin Siwek , Anna Tereszko , Anna Krupa , Amira Bryll , Adrian Chrobak


Objective: The occurrence of death by suicide in patients diagnosed with bipolar disorder is as much as 60 times greater than in the general population. Even during the state of euthymia patients are characterized by suicide risk. The aim of the study is to investigate the baseline brain activity in euthymic bipolar disorder patients in regard to suicide risk. We hypothesized that patients compared to healthy control group will demonstrate altered functional connectivity among resting state networks which will be directly related to current suicide risk. Method: 41 subjects were enrolled in the study consisting control group (n = 21) and euthymic bipolar disorder patients group (n = 20). Functional magnetic resonance imaging was used to evaluate resting state brain activity and ROI–ROI functional connectivity analysis was performed. Suicidal risk was estimated using The Suicide Behaviors Questionnaire-Revised. Results: A two sample t-test revealed decreased functional connectivity between regions involved in the salience network in patients compared to the control group. This decrease was negatively correlated with current suicide risk. Conclusion: Obtained results suggest the association between risk of suicide and activity of regions responsible for functions such as learning from mistakes, prospective thinking, and sensory integration.
Author Anna Sobczak
Anna Sobczak,,
, Bartosz Bohaterewicz (Wydział Psychologii w Warszawie)
Bartosz Bohaterewicz,,
- Wydział Psychologii w Warszawie
, Tadeusz Marek (USSH)
Tadeusz Marek,,
- SWPS University of Social Sciences and Humanities
, Magdalena Fafrowicz
Magdalena Fafrowicz,,
, Dominika Dudek
Dominika Dudek,,
, Marcin Siwek
Marcin Siwek,,
, Anna Tereszko
Anna Tereszko,,
, Anna Krupa
Anna Krupa,,
, Amira Bryll
Amira Bryll,,
, Adrian Chrobak
Adrian Chrobak,,
Journal seriesFrontiers in Human Neuroscience, ISSN 1662-5161, (N/A 100 pkt)
Issue year2020
Publication size in sheets0.5
Keywords in Englishneuroimaging, functional connectivity, resting state, bipolar disorder, suicide, euthymia, suicidal risk, fMRI
ASJC Classification2738 Psychiatry and Mental health; 2802 Behavioral Neuroscience; 2803 Biological Psychiatry; 2808 Neurology; 3206 Neuropsychology and Physiological Psychology
Languageen angielski
Altered Functional connectivity.pdf 1.17 MB
Additional file
osw_Bohaterewicz.pdf 95.34 KB
Score (nominal)100
Score sourcejournalList
Publication indicators Scopus SNIP (Source Normalised Impact per Paper): 2018 = 1.101; WoS Impact Factor: 2018 = 2.87 (2) - 2018=3.964 (5)
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