Prolonged exposure, paroxetine and the combination in the treatment of PTSD following a motor vehicle accident. A randomized clinical trial - The "TRAKT" study

Agnieszka Popiel , Bogdan Zawadzki , Ewa Pragłowska , Yona Teichman


Background and Objective: Little is known about direct comparisons of the efficacy of trauma-focused psychotherapies and SSRIs. This is the first randomized clinical trial comparing the efficacy of prolonged exposure (PE), paroxetine (Ph) and their combination (Comb) in a sample of adults diagnosed with PTSD following motor vehicle accidents (MVA).; Methods: A total of 228 people were randomly assigned to a twelve-week treatment of PE (N = 114), Ph (N = 57) or Comb (N = 57).; Results: The ITT analyses showed that the remission rate of PTSD was significantly greater after PE (65.5%) compared with Ph (43.3%), whereas Comb (51.2%) did not differ from either. The differences in dropout rates were not significant between treatments (18.4% - PE; 12.2% - Ph; 22.8% - Comb), while the differences in numbers of refusers were significant (3.5% PE <31.6% Comb <47.4% Ph; p < .01). The changes in self-rated PTSD were significant for each treatment and without significant differences between treatme
Author Agnieszka Popiel (Wydział Psychologii)
Agnieszka Popiel,,
- Wydział Psychologii
, Bogdan Zawadzki
Bogdan Zawadzki,,
, Ewa Pragłowska
Ewa Pragłowska,,
, Yona Teichman
Yona Teichman,,
Journal seriesJournal of Behavior Therapy and Experimental Psychiatry, ISSN 0005-7916, (A 30 pkt)
Issue year2015
Pages17 - 26
Publication size in sheets0.5
Keywords in EnglishAccidents, Traffic/*psychology, Implosive Therapy/*methods, Paroxetine/*pharmacology, Serotonin Uptake Inhibitors/*pharmacology, Stress Disorders, Post-Traumatic/*therapy, Adult, Combined Modality Therapy, Female, Follow-Up Studies, Humans, Male, Middle Aged, Paroxetine/administration & dosage, Serotonin Uptake Inhibitors/administration & dosage, Stress Disorders, Post-Traumatic/drug therapy, Treatment Outcome, Accidents, CBT, Combined, PTSD, Paroxetine, RCT, Treatment
ASJC Classification2738 Psychiatry and Mental health; 1201 Arts and Humanities (miscellaneous); 3203 Clinical Psychology; 3205 Experimental and Cognitive Psychology
Languageen angielski
2. Baza wiedzy A.Popiel Załącznik 2 JBTEP.pdf 1.08 MB
Additional file
A.Popiel Oświadczenie_publ 2017.pdf 294.38 KB
Score (nominal)30
Publication indicators Scopus SNIP (Source Normalised Impact per Paper): 2015 = 1.065; WoS Impact Factor: 2015 = 2.193 (2) - 2015=2.676 (5)
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