Chemokine alterations in bipolar disorder: A systematic review and meta-analysis

Błażej Misiak , Francesco Bartoli , Giuseppe Carrà , Monika Małecka , Jerzy Samochowiec , Konrad Jarosz , Anna Banik , Bartłomiej Stanczykiewicz

Abstract

We aimed to perform a systematic review and meta-analysis of studies examining the levels of chemokines in peripheral blood of patients with bipolar disorder (BD) and healthy controls. Meta-analysis was based on random-effects models with Hedges’g as the effect size estimate. We included 13 eligible studies (1221 BD patients and 663 controls). The following chemokines were analysed: interleukin-8 (IL-8), monocyte-chemoattractant protein-1 (MCP-1), eotaxin-1, eotaxin-2 and interferon-γ-induced protein 10 (IP-10). The levels of IL-8 (N = 8, g = 0.26, 95%CI: 0.11–0.41, p < 0.001), MCP-1 (N = 8, g = 0.40, 95%CI: 0.18–0.63), eotaxin-1 (N = 3, g = 0.55, 95%CI: 0.21–0.89, p = 0.001) and IP-10 (N = 4, g = 0.95, 95%CI: 0.67–1.22, p < 0.001) were significantly higher in BD patients as compared with controls. Subgroup analyses revealed that elevated levels of IL-8 (N=5, g=0.75, 95%CI: 0.42–1.07, p < 0.001) and MCP-1 (N=4, g=0.57, 95%CI: 0.28–0.86, p < 0.001) appeared only in BD patients during their depressive phase. Illness duration was associated with significantly lower levels of IL-8 in meta-regression analysis. In turn, elevated levels of IP-10 were present during euthymia (N=2, g=0.76, 95%CI: 0.43–1.10, p < 0.001) but not depression (N=2, g=1.81, 95%CI:−0.16 to 3.77, p = 0.072). The analysis of eotaxin-1 levels was mainly based on studies of euthymic BD patients (N = 3). Our results suggest that chemokine alterations in BD might be related to mood state. Elevated levels of IL-8 and MCP-1 might be specific to depression. Available evidence indicates that increased levels of eotaxin-1 and IP-10 appear in euthymia; however, more studies are needed to address these alterations in other mood states.
Author Błażej Misiak
Błażej Misiak,,
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, Francesco Bartoli
Francesco Bartoli,,
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, Giuseppe Carrà
Giuseppe Carrà,,
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, Monika Małecka
Monika Małecka,,
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, Jerzy Samochowiec
Jerzy Samochowiec,,
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, Konrad Jarosz
Konrad Jarosz,,
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, Anna Banik (Filia we Wrocławiu / Wydział Psychologii we Wrocławiu)
Anna Banik,,
- Wydział Psychologii we Wrocławiu
, Bartłomiej Stanczykiewicz
Bartłomiej Stanczykiewicz,,
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Journal seriesBrain Behavior and Immunity, [Brain, Behavior, and Immunity], ISSN 0889-1591, e-ISSN 1090-2139, (N/A 140 pkt)
Issue year2020
Vol88
Pages870-877
Publication size in sheets0.5
Keywords in EnglishCytokine, Chemokine, Inflammation, Immunity, Peripheral marker, Bipolar disorder
ASJC Classification2403 Immunology; 2802 Behavioral Neuroscience; 2807 Endocrine and Autonomic Systems
DOIDOI:10.1016/j.bbi.2020.04.013
Languageen angielski
File
Oswiadczenie_ABanik.jpeg 353.52 KB
Chemokine_tekst.pdf 549.8 KB
Score (nominal)140
Score sourcejournalList
Publication indicators Scopus SNIP (Source Normalised Impact per Paper): 2018 = 1.376; WoS Impact Factor: 2018 = 6.17 (2) - 2018=6.616 (5)
Citation count*3 (2020-09-22)
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* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.
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